COVRIN: One Health research integration on SARS-CoV-2 emergence, risk assessment and preparedness.
The Project #COVRIN
Coronavirus disease (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was first identified in December 2019 in Wuhan, China, and has since spread rapidly, evolving into a full-blown pandemic. This COVID-19 pandemic has an unprecedented societal and economic impact.
A main focus of the COVRIN project will be to reinforce collaboration and integration of research activities on SARS-CoV2. This project aims to integrate coronavirus research activities of all project partners. The project will have two main operational objectives:
- To identify the drivers for the emergence and spread of SARS-CoV2.
- To generate data and build models for risk assessment of SARS-CoV2.
Activities to connect with stakeholders and avoid overlaps with other projects will be a key focus and the project will split into four key research activities:
- Research on detection of SARS-CoV2 in animal species and the environment
- Research on SARS-CoV2 molecular and biological characterisation
- SARS-CoV2 surveillance and risk assessment, focussed on the animal human interface
- Coronavirus preparedness.
Within the overall One Health EJP strategic goals, the overall aim of the COVRIN project will be to generate and share data of integrative research activities on virus-host interactions, virus evolution and drivers for emergence, risk assessment and risk modelling, in order to increase the preparedness for future Coronavirus outbreaks.
Decaro, N., Grassi, A., Lorusso, E., Patterson, E. I., Lorusso, A., Desario, C., Anderson, E. R., Vasinioti, V., Wastika, C. E., Hughes, G. L., Valleriani, F., Colitti, B., Ricci, D., Buonavoglia, D., Rosati, S., Cavaliere, N., Paltrinieri, S., Lauzi, S., Elia, G., & Buonavoglia, C. (2021). Long-term persistence of neutralizing SARS-CoV-2 antibodies in pets. Transboundary and emerging diseases. 10.1111/tbed.14308. Advance online publication. DOI: https://doi.org/10.1111/tbed.14308
Gonzales, J. L., de Jong, M., Gerhards, N. M., & Van der Poel, W. (2021). The SARS-CoV-2 Reproduction Number R0 in Cats. Viruses. 13(12), 2480. DOI: https://doi.org/10.3390/v13122480
Hagag, I. T., Weber, S., Sadeghi, B., Groschup, M. H., & Keller, M. (2021). Impact of animal saliva on the performance of rapid antigen tests for detection of SARS-CoV-2 (wildtype and variants B.1.1.7 and B.1.351). Veterinary microbiology. 262, 109243. DOI: https://doi.org/10.1016/j.vetmic.2021.109243
Romito G., Bertaglia T., Bertaglia L., Decaro N., Uva A., Rugna G., Moreno A., Vincifori G., Dondi F., Diana A., Cipone M. (2021) Myocardial Injury Complicated by Systolic Dysfunction in a COVID-19-Positive Dog. Animals. 11(12):3506. DOI: https://doi.org/10.3390/ani11123506
2021). Differential susceptibility of SARS-CoV-2 in animals: Evidence of ACE2 host receptor distribution in companion animals, livestock and wildlife by immunohistochemical characterisation. Transboundary and Emerging Diseases, 1– 12. DOI: https://doi.org/10.1111/tbed.14232, , , , , , , , , , , , , , , , , (
Di Pasquale A., Radomski N., Mangone I., Calistri P., Lorusso A. and Cammà C. (2021). SARS-CoV-2 surveillance in Italy through phylogenomic inferences based on Hamming distances derived from pan-SNPs, -MNPs and -InDels. BMC Genomics. 22, 782. DOI: https://doi.org/10.1186/s12864-021-08112-0