Antibiotic Resistance Dynamics: the influence of geographic origin and management systems on resistance gene flows within humans, animals and the environment. – ARDIG
Project Coordinator: Muna Anjum (APHA)
Project Partners: Roberto La Ragione (UoS); Bernd-Alois Tenhagen (BfR); Marianne Sunde (NVI); Phillippe Glaser (IP); Bruno Gonzalez-Zorn (UCM); Jean-Yves Madec (ANSES); Michael Brouwer (WUR); Tim Eckmanns (RKI); Matthew Ellington (PHE).
Project length: 3 years
Project budget: €3,000,000
AMR is a global threat; the control and understanding of AMR is a major theme of the EJP and the EU. Harmonised monitoring and reporting of AMR is carried out under EU Directives annually. However, data from the EU surveillance systems can be difficult to extrapolate, and harmonization of data between the veterinary and medical sectors can be difficult due to substantial difference in treatment schedules and population dynamics. Furthermore, only phenotypic data is currently reported which precludes gathering information on resistance mechanisms and their ability to transfer horizontally between bacteria via mobile genetic elements or indeed other means. This proposal brings together ten leading experts on AMR from both veterinary and human sectors in Europe, across five Member States and one non-Member State. The project will be multi-facetted, multidisciplinary, performing cutting edge science to examine the dynamics of AMR in different epidemiological units (the human, animal, food and environment) from countries which represent significant difference in their usage of antimicrobial agents and AMR prevalence, both in the human and veterinary sectors, as well as different climate, management systems and the potential for transmission of resistance. We will explore the ecological impact of administration of antibiotics to humans and animals, and their environment, across six different geographic regions using a One Health approach, to get a better understanding of the types of resistances, their prevalence and variation in different populations (animals of various species reared under different management systems, and humans under treatment) over time, so the occurrence of multi-drug resistant (MDR) superbugs can be controlled. The aims of this proposal are divided into four different work packages: EU and national surveillance of AMR and antibiotic usage (WP1); Longitudinal studies of AMR persistence (WP2); AMR characterization, transmission of plasmids and fitness of MDR isolates (WP3); and Project coordination and management (WP4); which together will serve to inform on the dynamics of AMR across these six regions. It is expected that the results will help identify factors influencing the transmission of AMR between animals, humans, food and the environment which can be applied not only to provide a basis to improve existing national surveillances, but also to aid in the design of new or improved global AMR surveillances strategies, as well as risk and transmission models for assessing future control measures and mitigation of risk posed by AMR. The knowledge gathered can also serve, in the future, for development of novel targeted diagnostic applications for rapid surveillance and control.
Figure 1. Graphical presentation of how each WP and Task fits together in this proposal.