IDEMBRU

IDEMBRU: Identification of emerging Brucella species: new threats for human and animals

Start: 1 January 2020
Duration: 2.5 Years
Domain: Emerging Threats
Key Words: emerging Brucella, reservoir, virulence, whole genome sequencing, RNA detection
Contact: Claire Ponsart (ANSES)

The Project #IDEMBRU

Brucellosis is a highly contagious zoonosis usually caused by ingestion of unpasteurised milk or undercooked meat from infected animals, or close contact with their secretions. Brucellosis is one of the most widespread zoonotic diseases globally, with 500,000 new human cases estimated each year. For many years six ‘classical’ Brucella species were identified but, since the late 1990’s, several new Brucella species (including B. inopinata, B. microti and B. vulpis) were isolated from humans, wild animals and/or environmental sources demonstrating a wider range of hosts and new potential zoonotic threats. Some of these species are genetically and/or phenotypically atypical in comparison to the ‘classical’ species.

In 2017, European amphibians were reported to be infected by one such recently identified species (B. microti), already reported in rodents, foxes and wild boar, thus confirming the broad host range of emerging atypical Brucella. These emerging Brucella isolates need to be further investigated to evaluate their geographical distribution and host range, to assess their zoonotic potential, and to compare their virulence and persistence markers with classical species.

Other emerging situations concern classical Brucella species, such as Brucella suis and Brucella melitensis, which circulate in wildlife reservoirs with the potential to spillover to domestic animals and humans or which are emerging in Western Europe as a result of pet movements (Brucella canis). Currently only some classical Brucella species are subject to statutory control and surveillance strategies in domestic animals in Europe. Therefore, these species are potentially underdiagnosed in wildlife. Some Brucella species are classified into biovars, and species and biovars vary in terms of pathogenicity for humans. The most studied Brucella species and biovars correspond to those presenting the known highest risk of transmission to humans while others are poorly characterised. Finally, emerging reservoirs of classical Brucella could be linked with new consumption patterns, with developing practices of organic and raw milk products, with imported animal-derived products from different origins or with emerging animal movement pathways

An exhaustive evaluation and understanding of emerging non-classical Brucella and emerging reservoirs of classical species is needed to protect people and animals from infection. This IDEMBRU project aims to develop a toolbox focusing on emerging Brucella species and reservoirs in order to ensure rapid detection, identification and characterisation. The project will include i) the detection and investigation of these pathogens from different sources under various epidemiological contexts in terms of natural landscape, livestock demographics, and wildlife populations (Mediterranean, East, North and West Europe); ii) the characterisation of the emerging Brucella species by identification of genomic and phenotypic variability via high throughput methods (NGS, molecular tests, proteomics, metabolomics) ; iii) the understanding of virulence and zoonotic potentials through in vivo and in vitro infection models ; iv) the development of a toolkit for the integration of data from emerging Brucella and as a resource to guide characterisation of emerging Brucella.

Project Updates

On December 11th the first annual JRP-17 IDEMBRU workshop was organised. Under the cover of COVID-19 pandemics, the workshop had to be organised online, with all eight consortium members and 26 participants in total. The topics of the workshop were advancements made, difficulties, mutual collaboration and room for improvement as well as further organisation of the project due to the limited time and ongoing sanitary crisis. Strategic progress points were identified and plan for the next year established. One external keynote speaker presented an early warning system for detection of mandatory reportable Brucella species (Francesco Berlingieri, DG SANTE). Very big thank you to Marie-France Devaux who prepared logistical support as well as the whole LRUE Brucellosis team from UZB, Animal health laboratory – ANSES for making this meeting possible (Claire Ponsart, Vitomir Djokic, Acacia Ferreira Vicente, Luca Freddi, Guillaume Girault, Lisa Laboutière, Ludivine Perrot, Fathia Petot-Bottin and Maëline Ribeiro).

Project Events

Brucella canis workshop 18th May 2021

IDEMBRU Workshop- 11th December 2020, Online

Project Kick-off meeting- 13th November 2019, Berlin, Germany

Publications

OpenAIRE Publications

wso shellkadına özelkadın newsbacklink albacklink satışinstagram takipçi hilesimeme küçültmewso shellworld newstatto girlshacklink seoseo analysismakale programıbacklink salessite analysispubg hile alseo sorgulamahacklink panelseo analysisseo sorgulagoogle newshacklink satışbacklinkbacklink satışseo araclarıseo analizsite analizwebroot shellbypass shellr57 shelladana escortcanlı bahisadana eskortnevşehir escortbedava bonus veren bahis siteleribedava bonusdeneme bonusu30 tl bonus veren bahis sitelerihoşgeldin bonusuhoşgeldin bonusu veren bahis siteleribahis siteleribahiskaçak iddaacanlı bahisTürkçe Bahis Şirketlerisex hikayeleriporno hikayelerkayseri escortpendik escortsex hikayependik escorttuzla escortpendik escortkurtkoy escortkartal escortapartman kamera sistemikamera sistemimaltepe escortporno izleporno izleümraniye escortizmit escort bayankocaeli escort bayanizmit escortc99 shellc99 shellhtml kod şifrelemeseo newshacklinkbacklink alçorlu escortçerkezköy escortsivas escortmanisa escortizmir escorthatay escorterzurum escortbalikesir escorturfa escorttrabzon escorttekirdag escortsamsun escortadana escortankara escortantep escortaydin escortbursa escortdenizli escortsakarya escortordu escortmugla escortdiyarbakir escorteskisehir escortkayseri escortkocaeli escortkonya escortmalatya escortmaras escortmardin escortmersin escortizmir escortankara escortmersin escorteskişehir escortgaziantep escortsakarya escortkayseri escortantalya escortistanbul escortbursa escortadana escortwso shellsite hız testiadıyamanescortafyon escortağrı escortaksaray escortamasya escortardahan escortartvin escortaydın escortbalıkesir escortbartın escortbatman escortbayburt escortbilecik escortbingöl escortbitlis escortçanakkale escortçankırı escortçorum escortdenizli escortdiyarbakır escortdüzce escortedirne escortelazığ escorterzincan escortbolu escortburdur escortgümüşhane escorthatay escortığdır escortısparta escortmaraş escortkarabük escortkars escortkastamonu escortkilis escortkırıkkale escortkırklareli escortkırşehir escortkocaeli escortkonya escortkütahya escortmalatya escortmanisa escortmardin escortmuğla escortmuş escortnevşehir escortniğde escortordu escortosmaniye escortrize escortsamsun escorturfa escortsiirt escortsinop escortşırnak escortsivas escorttekirdağ escorttokat escorttrabzon escorttunceli escortuşak escortvan escortyozgat escortyalova escortzonguldak escortkıbrıs escortpendik escortesenyurt escortzeytinburnu escortküçükçekmece escortbeşiktaş escorttuzla escortbeykoz escortfatih escortsancaktepe escortarnavutköy escortbağcılar escortümraniye escortbeyoğlu escortüsküdar escortesenler escortmecidiyeköy escortsarıyer escortetiler escortlevent escortbebek escortgaziosmanpaşa escortkartal escortbaşakşehir escortşişli escorthalkalı escortbahçelievler escortortaköy escorteyüp escortbahçeşehir escortkağıthane escorttaksim escortçekmeköy escortbayrampaşa escortbeylikdüzü escortkadıköy escortataşehir escortbakırköy escortataköy escortnişantaşı escortkozyatağı escortavcılar escortbüyükçekmece escortkurtköy escortiçerenköy escortbostancı escortşirinevler escorterenköy escortadana escortadıyaman escortafyon escortağrı escortaksaray escortamasya escortankara escortantalya escortardahan escortartvin escortaydın escortbalıkesir escortbartın escortbatman escortbayburt escortbilecik escortbingöl escortbitlis escortbolu escortburdur escortbursa escortçanakkale escortçankırı escortçorum escortdenizli escortdiyarbakir escortdüzce escortedirne escortelazığ escorterzincan escorterzurum escorteskişehir escortantep escortgiresun escortgümüşhane escorthakkari escorthatay escortığdır escortistanbul escortizmir escortkarabük escortkaraman escortkars escortkastamonu escortkayseri escortkıbrıs escortkilis escortkırıkkale escortkırklareli escortkırşehir escortkocaeli escortkonya escortkütahya escortmalatya escortmanisa escortmaraş escortmardin escortmersin escortmuğla escortmuş escortnevşehir escortniğde escortordu escortosmaniye escortrize escortsakarya escortsamsun escortsiirt escortsinop escortmozrankGameloopporno izleçekiliş sitesihtml code encryptionserver scanwso shelloyun indirsunucu taramasite speed testinstagram takipçi hilesiWordpress Free Themeswordpress free temahtml kod şifrelemesunucu taramaTanıtım Yazısıwordpress themesseowordpress ücretsiz temaWho islogsuz shell indirlitespeed bypass shellindoxploit shellphp shellgoogle sıra buluculitespeed bypass shellbacklink sorgulamaeryaman escortistanbul bayan escortankara escorthacklink satışbacklink satışhacklink panelhacklinkerzurum escortgiresun escortbest stethoscoperaycon reviewsBest Dog Crateshapermint bra reviewswireless earbudsBest Gaming Monitorsviagra siparişlifta 20 mgcialis fiyatviagra 100 mg fiyatcialis jelviagra satın alcialis 5 mg fiyatviagra satın alviagra fiyatıdegravigrandedegra 100 mgorcafilcialis nedircialis 20 mg eczane fiyatıcialis fiyatcialis 20 mgcialis 100 mgviagra fiyatliftalifta 5 mghardciscialis eczanecialis 5 mg fiyatıcialis 100 mg fiyatcialis 5 mgviagra fiyatlarıviagra satışonline eczane viagraviagra eczanecialis 20 mgcialis 100 mgcialis hapcialis 20cialis eczanecialis satışcialis fiyatlarıcialis fiyatıviagra fiyatviagra fiyatlarıviagra eczaneviagra satın alpfizer viagra satışonline eczane viagrapfizer viagra satın alviagra siparişviagra sipariş hattıviagra fiyat 2021online viagra siparişviagra fiyat 2021 eczaneviagra fiyat eczanecialis 5 mgkamagra satın alkamagrakamagra jelkamagra jel siparişkamagra siparişkamagra fiyatkamagra jel fiyatıkamagra fiyatıkamagra 100mgkamagra 100mg fiyatsüper kamagrakamagra nedirSincan escortAnkara rus escortsultangazi escortbingöl escortsancaktepe escorteskişehir escortkırklareli escortçekmeköy escortbodrum escortkuşadası escortc99 shellc99 shelllifta 20 mgliftalifta 20lifta 20 mg nedirlifta nedirhacklink seokuşadası escortbeylikdüzü escortkarşıyaka escortbornova escortçeşme escortbuca escortalsancak escortkonak escortgöztepe escortçankaya escortankara escortankara escort bayanescort ankaraescort ankaraankara escort bayanankara escortEscort ankaraankara escort bayanankara escortEscort antalyaantalya escort bayanantalya escortankara escort bayanEscort ankaraAnkara escort kızlarankara escortankara escort bayanescort ankaraEscort antalyaÇankaya escort bayanantalya escortKeçiören escort bayanEryaman escortKeçiören EscortEscort sincanEtlik escort bayanEryaman escort bayanÇankaya escortSincan escort bayanantalya escort bayanKızılay escort bayanEtlik escortKızılay escortEscort eryamaninstagram takipci hilesiinstagram takipci hilesismm panelsmm panelinsagram Free Followersinstagram Followers Freeinstagram takipci satın alinstagram unfollowinstagram beğeni hilesiinstagram Followersinstagram free likesinstagram takipci hilesiinstagram takipci hilesiinstagram takipci hilesiphp encodebase64 encodecialis fiyatcialis fiyatlarıcialis 20 mgcialiscialis 100 mgcialis 5 mgcialis satışviagra fiyatıTuzla EscortMalatya EscortÇankaya EscortEryaman EscortPendik EscortKartal EscortKurtkoy Escortkayseri escortadana escortamasya escortbartın escortbatman escortadıyaman escortbayburt escortartvin escortantalya escortaydın escortbalıkesir escortağrı escortafyon escortbilecik escortbingöl escortburdur escortbolu escortbursa escortçanakkale escortçorum escortdüzce escortedirne escortçankırı escortdiyarbakır escortdenizli escortelazığ escortgiresun escorthatay escortkaraman escortısparta escortmaraş escortkars escortkastamonu escortgümüşhane escorteskişehir escortkarabük escorterzincan escorterzurum escortkayseri escortkütahya escortkırıkkale escortkırklareli escortmardin escortkonya escortmuğla escortkocaeli escortmanisa escortmersin escortkırşehir escortmalatya escortmuş escortosmaniye escortnevşehir escortniğde escortsamsun escortordu escortrize escorturfa escortsakarya escortsinop escorttekirdağ escortyalova escortzonguldak escortyozgat escortsivas escorttunceli escorttrabzon escortuşak escorttokat escortvan escortşırnak escortsivas escortuşak escorttunceli escortkıbrıs escortkıbrıs escorttekirdağ escortyozgat escorttokat escortzonguldak escorttrabzon escortvan escortyalova escortantalya escortankara escortizleANKARA ESCORTviagra fiyatinstagram followers freeEreksiyon Haplarıorcafil 5 mgflynta 5 mglifta 5 mgflynta 20 mglifta 20 mgdegra fiyatdegra 100 mgsildegra 100 mgsildegrasinegravigrandevigrande 100 mgcombo 100 mgvigaroojeligrasisli escortankara escorteskişehir escortizmir escortantalya escorthurma escortkonyaaltı escortlara escortANKARA ESCORTankara escortANKARA BAYAN ESCORTistanbul escort