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The Project #ORION

Start: 1 January 2018
Duration: 3 Years
Domain: Integrative Activity
Keywords:  One Health, Surveillance data harmonisation, Guidelines, Knowledge
Contact: Matthias Filter (BfR)

ORION: One Health Surveillance Initiative on Harmonisation of Data Collection and Interpretation

The ORION project developed and optimized resources supporting the implementation of the One Health paradigm.

These solutions were evaluated in a number of national One Health (OH) pilots as well as in a supra-national pilot with EFSA and ECDC.

One of the main ORION project outcomes is the so-called One Health Surveillance (OHS) Codex, which is a framework supporting the implementation of the One Health paradigm. This framework was implemented as a  continuously updateable online resource.

It is founded on the ORION requirement analysis where ORION partners jointly concluded that surveillance data integration in a One Health context requires a number of specific actions on different problem types by various stakeholders along the full surveillance pathway. This finding led to the design of an extendable OHS Codex structure that covers four main principles. Each principle represents an area, where specific actions could help to adopt the One Health paradigm. This structure enabled ORION partners to develop and integrate a broad spectrum of innovative solutions, resources and findings into a consistent overarching framework, including lessons learned from national pilots.

Among others, the OHS Codex encompass the “One Health Report Annotation Checklist” (OH-CRAC), National OHS Report Templates, the One Health EJP Glossary, a OHS Inspiration catalogue, the OH Surveillance Pathway Visualization, the OH Knowledge Base – Surveillance systems, the Sequencing for Surveillance (SfS) Handbook and the Health Surveillance Ontology.

In several national OH pilots country specific solutions were established that created direct impact on cross-sector communication, surveillance data exchange and interpretation. For example, in the WP2-NGS pilot the first cross-sector Integrated Rapid Infectious Disease Analysis (IRIDA) and NGS data analysis platform was established at the Norwegian Research and Education Cloud. As a result, there is an increased collaboration and information exchange between the veterinary and public health sectors in Norway. The Danish pilots contributed to improved OH reporting, e.g. the Salmonella and Campylobacter chapter in DANMAP 2019, and the Danish national surveillance system for AMR and AMU accessible here.

They also established a sequencing based Campylobacter surveillance system that will be extended in the future into a platform for real-time surveillance data and result sharing. The Swedish pilot led to the implementation of new work procedures in the process of generating the annual surveillance reports on zoonotic diseases with an improved collaboration among the national OH sectors. The revised processes helped to identify and address bottlenecks in cross-sectoral interoperability and FAIRness of surveillance results. Innovative data interoperability solutions supporting data interoperability were developed and tested.

On international level, the ORION project performed a number of activities to share knowledge with international stakeholders like EFSA and ECDC, for example in a dedicated pilot project. In addition, a number of ORION solutions were integrated into the Surveillance and Information Sharing Operational Tool (SISOT) of WHO/FAO/OIE.

Members of the ORION project presented research results at various international conferences, e.g. ASM2019, ASM2020, ASM2021, the 6th World One Health Congress etc., conducted several webinars and organized international workshops with other research projects and institutes, e.g. the NGS workshop 2020, the CPD2021 module, the ASM2021 Satellite Workshop Software Fair. ORION partners published a number of scientific publications in peer-reviewed journals.

Project Assets

Foddai, A., Nauta, M., Ellis-Iversen, J. (2023). A model using an inter-sectorial data integration process indicates that reducing Campylobacter cross-contamination at slaughter mitigates the risk of human campylobacteriosis effectively. Microbial Risk Analysis. 23, 100248. DOI: https://doi.org/10.1016/j.mran.2023.100248

Foddai, A., Takeuchi-Storm, N., Høg, B. B., Kjeldgaard, J. S., Andersen, J. K., Ellis-Iversen, J. (2022). Assessing Campylobacter cross-contamination of Danish broiler flocks at slaughterhouses considering true flock prevalence estimates and ad-hoc sampling. Microbial Risk Analysis. 21, 100214. DOI: https://doi.org/10.1016/j.mran.2022.100214

Günther, T., Kramer-Schadt, S., Fuhrmann, M., & Belik, V. (2022). Environmental factors associated with the prevalence of ESBL/AmpC-producing Escherichia coli in wild boar (Sus scrofa)Frontiers in Veterinary Science. 9, 980554. DOI: https://doi.org/10.3389/fvets.2022.980554

Lopez de Abechuco, E., Dórea, F., Buschhardt, T., Scaccia, N., Günther, T., Foddai, A., Dups-Bergmann, J., & Filter, M. (2022). One Health Consensus Report Annotation Checklist (OH-CRAC): A cross-sector checklist to support harmonized annotation of surveillance data in reports. Zoonoses and public health. 69(6), 606–614. DOI: https://doi.org/10.1111/zph.12947

Foddai A., Nauta M., Ellis-Iversen J. (2022). Risk-based control of Campylobacter spp. in broiler farms and slaughtered flocks to mitigate risk of human campylobacteriosis – A One Health approach. Microbial Risk Analysis, 100190, ISSN 2352-3522. DOI: https://doi.org/10.1016/j.mran.2021.100190

Scaccia, N., Günther, T., Lopez de Abechuco, E., Filter, M. (2021). The Glossaryfication Web Service: an automated glossary creation tool to support the One Health community. Research Ideas and Outcomes, 7: e70183. DOI: https://doi.org/10.3897/rio.7.e70183

Buschhardt, Tasja., Günther, Taras., Skjerdal, Taran., Torpdahl, Mia., Gethmann, Jörn., Filippitzi, Maria-Eleni., Maassen, Catharina., Jore, Solveig., Ellis-Iversen, Johanne. (2021). A one health glossary to support communication and information exchange between the human health, animal health and food safety sectors. One Health, 13. DOI: https://doi.org/10.1016/j.onehlt.2021.100263

Filter, Matthias., Buschhardt, Tasja., Dórea, Fernanda., Lopez de Abechuco, Estibaliz., Günther, Taras., Sundermann, Esther M.; Gethmann, Jörn., Dups-Bergmann, Johanna., Lagesen, Karin., Ellis-Iversen, Johanne. (2021). One Health Surveillance Codex: promoting the adoption of One Health solutions within and across European countries. One Health, 12. DOI: https://doi.org/10.1016/j.onehlt.2021.100233

Joensen, KG., Kiil, K., Gantzhorn, MR.,Nauerby, B., Engberg, J., Holt, HM.,Nielsen, HL.,Petersen, AM., Kuhn, KG.,Sandø, G.,Ethelberg, S., Nielsen, EM. (2020). Whole-Genome Sequencing to Detect Numerous Campylobacter jejuni Outbreaks and Match Patient Isolates to Sources, Denmark, 2015–2017. Emerging Infectious Diseases, 26(3), 523-532. DOI: https://dx.doi.org/10.3201/eid2603.190947

Houe, H., Nielsen, SS., Nielsen, LR., Ethelberg, S., Mølbak, K. (2020). Opportunities for Improved Disease Surveillance and Control by Use of Integrated Data on Animal and Human Health. Frontiers in Veterinary Medicine, 6: 301, pp. 1-8. DOI: https://doi.org/10.3389/fvets.2019.00301

Stelzer, S., Basso, W., Benavides Silván, J., Ortega-Mora, L.M., Maksimov, P., Gethmann, J., Conraths, F.J.,  Schares, G. (2019). Toxoplasma gondii infection and toxoplasmosis in farm animals: Risk factors and economic impact. Food and Waterborne Parasitology, 12, pp. e00037. DOI: https://doi.org/10.1016/j.fawpar.2019.e00037

The National Food Institute Technical University of Denmark have produced an Inspiration and Ideas report regarding One Health Integration in Surveillance.

Authors: Johanne Ellis-Iversen, Channie Kahl Petersen, Birgitte Helwigh
Affiliation: EpiRisk, Division of Risk Assessment and Nutrition, National Food Institute, DTU


Project Updates

The ORION project have created a One Health Glossary to harmonise terminology across different sectors.

To find out how to use the glossary to its full potential, you can watch the recent ORION webinar.

Project Events

ORION Annual Meeting 16th-18th January 2019

ORION Final Consortium Meeting- 9th-11th March 2021

Orion project case study flyer



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