Uppsala, Uppsala län, Sweden

Rua Rio Ave 1600, Carnide, Área Metropolitana de Lisboa, Portugal

Avenida da República, Oeiras e São Julião da Barra, Paço de Arcos e Caxias, Área Metropolitana de Lisboa, Portugal

Aleja Partyzantów 57, Puławy, województwo lubelskie, Poland

Ullevålsveien 68, Oslo, Oslo, Norway

Houtribweg 39, Lelystad, Flevoland, The Netherlands

Antonie van Leeuwenhoeklaan 9, De Bilt, Utrecht, The Netherlands

Bettola-Zeloforomagno, Lombardy, Italy

Teramo, Abruzzo, Italy

Viale Regina Elena, Rome, Lazio, Italy

Daphne Jackson Road, Guildford, England, United Kingdom

Addlestone, England, United Kingdom

Avenida Puerta de Hierro, Madrid, Comunidad de Madrid, Spain

Madrid, Comunidad de Madrid, Spain

Südufer 10, Greifswald, Mecklenburg-Vorpommern, Germany

Max-Dohrn-Straße 8, Berlin, Berlin, Germany

Hudcova 296, Brno, Jihovýchod, Czech Republic

Rue Juliette Wytsman - Juliette Wytsmanstraat 14, Ixelles - Elsene, Région de Bruxelles-Capitale - Brussels Hoofdstedelijk Gewest, Belgium

Spargelfeldstraße 191, Süßenbrunn, Wien, Austria

14 Rue Pierre et Marie Curie, Maisons-Alfort, Île-de-France, France

ohejp covrin project logo

The Project #COVRIN

Start: 1st March 2021
Duration: 2 Years
Domain: Emerging Threats
Keywords: Coronavirus, SARS-CoV-2, COVID-19, Acute Respiratory Disease, preparedness, zoonoses, wildlife, animals
Contact: Wim van der Poel (WBVR) &
Dan Horton (UoS)

COVRIN: One Health research integration on SARS-CoV-2 emergence, risk assessment and preparedness.

Coronavirus disease (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), first identified in December 2019. COVID-19 has since spread rapidly, evolving into a pandemic with unprecedented societal and economic impact.

A main focus of the COVRIN project was to reinforce collaboration and integration of research activities on SARS-CoV-2. The aim of this project was to integrate coronavirus research activities of all project partners. The project had two main operational objectives:

  1. To identify the drivers for the emergence and spread of SARS-CoV-2.
  2. To generate data and build models for risk assessment of SARS-CoV-2.

Activities to connect with stakeholders and avoid overlaps with other projects were a key focus and the project was split into four key research activities:

  1. Research on detection of SARS-CoV2 in animal species and the environment.
  2. Research on SARS-CoV2 molecular and biological characterisation.
  3. SARS-CoV2 surveillance and risk assessment, focused on the animal human interface.
  4. Coronavirus preparedness.

Project Outputs and Outcomes

  • Key outputs
    • Shared molecular tests
    • Shared immunoassays
    • Shared cell line and animal models
  • Expected implementations
    • Improved reference laboratory testing procedures
    • Improved risk modelling approaches
  • Expected impact of the research
    • Preparedness research
    • Risk assessments and control research
  • Societal and policy impact
    • Improved risk assessment
    • Improved health risks control

Project Assets

Guo, R., Wolff, C., Prada, J., & Mughini-Gras, L. (2023). When COVID-19 sits on people’s laps: A systematic review of SARS-CoV-2 infection prevalence in household dogs and cats. One Health. 16, 100497. DOI:

Moreno, A., Lelli, D., Trogu, T., Lavazza, A., Barbieri, I., Boniotti, M., Pezzoni, G., Salogni, C., Giovannini, S., Alborali, G., Bellini, S., Boldini, M., Farioli, M., Ruocco, L., Bessi, O., Maroni Ponti, A., Di Bartolo, I., De Sabato, L., Vaccari, G., Belli, G., Margutti, A., Giorgi, M. (2022). SARS-CoV-2 in a Mink Farm in Italy: Case Description, Molecular and Serological Diagnosis by Comparing Different Tests. Viruses. 14(8), 1738. DOI:

Newman, J., Thakur, N., Peacock, T.P., Bialy, D., Elreafey, A.M., Bogaardt, C., Horton, D.L., Ho, S., Kankeyan, T., Carr, C., Hoschler, K., Barclay, W.S., Amirthalingam, G., Brown, K., Charleston, B., Bailey, D. (2022). Neutralising antibody activity against SARS-CoV-2 variants, including Omicron, in an elderly cohort vaccinated with BNT162b2. Nature Microbiology. 7, 1180–1188. DOI:

Mendez, A., Jiménez-Clavero, M.A., Calvo, C., Pérez-Ramírez, E.,  Fernández-Pinero, J., Llorente, F., Sainz, T., Aguilera-Sepúlveda, P., Alcolea, S., Escolano, L., Cano, C., Novoa, I., De la Torre, A. & Iglesias, I. (2022). SARS-CoV-2 in pets of infected family groups in a severely affected region in Spain. International Journal of Infectious Diseases. 116 (Supplement), S25. DOI:

Decaro, N., Grassi, A., Lorusso, E., Patterson, E. I., Lorusso, A., Desario, C., Anderson, E. R., Vasinioti, V., Wastika, C. E., Hughes, G. L., Valleriani, F., Colitti, B., Ricci, D., Buonavoglia, D., Rosati, S., Cavaliere, N., Paltrinieri, S., Lauzi, S., Elia, G., & Buonavoglia, C. (2021). Long-term persistence of neutralizing SARS-CoV-2 antibodies in pets. Transboundary and emerging diseases. 1-4. DOI:

Gonzales, J. L., de Jong, M., Gerhards, N. M., & Van der Poel, W. (2021). The SARS-CoV-2 Reproduction Number R0 in Cats. Viruses. 13(12), 2480. DOI:

Hagag, I. T., Weber, S., Sadeghi, B., Groschup, M. H., & Keller, M. (2021). Impact of animal saliva on the performance of rapid antigen tests for detection of SARS-CoV-2 (wildtype and variants B.1.1.7 and B.1.351). Veterinary microbiology. 262, 109243. DOI:

Romito G., Bertaglia T., Bertaglia L., Decaro N., Uva A., Rugna G., Moreno A., Vincifori G., Dondi F., Diana A., Cipone M. (2021) Myocardial Injury Complicated by Systolic Dysfunction in a COVID-19-Positive Dog. Animals. 11(12):3506. DOI:

Lean F. Z.X.Núñez A.Spiro S.Priestnall S. L.Vreman S.Bailey D.James J.Wrigglesworth E.Suarez-Bonnet A.Conceicao C.Thakur N.Byrne A. M.P.Ackroyd S.Delahay R. J.van der Poel W. H. M.Brown I. H.Fooks A. R., Brookes S. M. (2021). Differential susceptibility of SARS-CoV-2 in animals: Evidence of ACE2 host receptor distribution in companion animals, livestock and wildlife by immunohistochemical characterisationTransboundary and Emerging Diseases1– 12. DOI:

Di Pasquale A., Radomski N., Mangone I., Calistri P., Lorusso A. and Cammà C. (2021). SARS-CoV-2 surveillance in Italy through phylogenomic inferences based on Hamming distances derived from pan-SNPs, -MNPs and -InDels. BMC Genomics. 22, 782. DOI:

D0.1.2- First management report

D0.2.1- First annual communication report

D0.3.1- Database of COVID-19 research activities

D0.3.2- Report on the COVRIN kick-off meeting – March 2021

D0.3.3- Report Mid-term meeting (presentations)

D0.3.4- Report on Final meeting Dec 2022

D0.3.4- Slide deck for Final meeting Dec 2022

D0.3.1- Scoping review of European Union-supported COVID-19 research activities

D1.1.1 & D1.1.2- Report on available data from SARS-CoV-2 genome detection in companion animals livestock and wildlife

D2.1.1- Report on the established website protocol repository

D2.1.2 – Report on the comparisons of variants and reference sample exchange – Bioinformatics Ring Trial

D.2.1.3- Report on the development of an algorithm for novel virus assessment

D2.2.1- Report on cell line sensitivities – species and virus growth characteristics

D2.2.3- Report on complex culture viral characterisation

D2.3.2- Report on pathology per species and investigative toolboxes

D2.3.3- Establishment of virus-host interaction parameters

D2.4.1- Collated partner outcomes of virus trait change as a result of species change including cell receptor affinity

D2.4.2- Report on in silico and antigenic cartography analysis of antigenic site adaptation traits

D2.4.3- Undertake and report on a virus variant in vivo follow-up study

D3.1.1- Report on the format and procedure for integration of SARS-CoV-2 surveillance data

D3.1.2- Database on sampling on wildlife, food producing animals, pets, and the environment

D.3.1.3 Report on the investigation and possibilities of integration

D3.2.1 – Review of surveillance activities carried out by member countries

D3.2.2- Report on key stakeholders across member countries and opportunities for alignment of One Health surveillance activities

D3.3.1- Report on epidemiological survey design and clinical data

D3.3.1- Report on epidemiological survey design and clinical data (including anamnesis and lab results)

D3.3.2- Report on the epidemiological survey results and risk factor assessment for pet human SARS-Cov-2 transmission

D3.4.1- Overview of models and parameters to assess transmission in animals

D3.4.2- Systematic review report and quantification of transmission parameters for different animal species (cats)

D3.4.2- Systematic review report and quantification of transmission parameters for different animal species (non-human primates)

D3.4.2- Systematic review report and quantification of transmission parameters for different animal species (hamsters & ferrets)

D3.4.2- Systematic review report and quantification of transmission parameters for different animal species

D3.4.4- Report on SR of challenge experiments using different host species

D3.4.5- Report describing the transmission characteristics of the mink outbreaks for the countries where data was available

D4.31- Final report of JIP COVRIN and evaluation report

D4.3.2- Report of pan coronavirus PCR screening, plus next generation sequencing of samples and viral diversity over time

D.4.3.3- Report of coronavirus contaminations in wildlife species

D4.3.4 – Report on risk assessment and modelling of animal coronavirus evolution



Project Events

Virtual kick-off meeting- 30th March 2021

Online Workshop “SARS-CoV-2 in Wildlife”- 22nd February 2022, online & hosted by the university of Surrey

COVRIN Overview presentation at OHEJP ASM 2022- 11-13th April 2022, Orvieto, Italy

Mid-term meeting- 27th June 2022, online



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