RaDAR

RaDAR: Risk and Disease burden of Antimicrobial Resistance

Start: 1 January 2018
Duration: 2 Years
Domain: Antimicrobial Resistance 
Keywords: Antimicrobial resistance, risk assessment, transmission, disease burden, evidence synthesis
Contact: Eelco FRANZ (RIVM)

The Project #RADAR

The RaDAR project aims to generate consensus estimates for sources attribution, risks of exposure and disease burden of AMR by integrating available data from various sources.

Resistance mechanisms emerge and spread globally. Circulation of antibiotic resistant bacteria in food and the environment and the resulting exposure of human beings to these bacteria may be significant. In general, information on the overall exposure to AMR from food and the environment is scarce. Therefore efforts are needed to fill data gaps and systematically integrate data into consensus estimates for sources attribution, risks of exposure and disease burden.

The RaDAR project aims at filling these gaps with a multidisciplinary and cross-member-state approach by:

  1. Addressing the relative and absolute contribution of animal and environmental sources to the public health burden of AMR,
  2. Linking data on antimicrobial consumption and the effects of different kinds of antimicrobial use on AMR in animal husbandry,
  3. Modeling the spread of resistance determinants in microbial communities, the environment and along the food chain,
  4. Quantifying human exposure and disease burden.

The project will develop generic risk and transmission models that may be adapted to various bacterial species and resistance determinants. It will generate consensus estimates for sources attribution, risks of exposure and disease burden of AMR by integrating available data from various sources and will lead to a consolidation of the international cooperation with respect to the assessment of risks related to the complex AMR problem.

Publications

Douarre, P E, Mallet, L, Radomski, N, Felten, A, Mistou, M. (2020). Analysis of COMPASS, a New Comprehensive Plasmid Database Revealed Prevalence of Multireplicon and Extensive Diversity of IncF Plasmids. Frontiers in Microbiology, 11, pp. 1-15. DOI: https://doi.org/10.3389/fmicb.2020.00483. 

Mughini-Gras, L, Dorado-García, A, van Duijkeren, E, van den Bunt, G, Dierikx, CM, Bonten, MJM, Bootsma, MCJ, Schmitt, H,  Hald, T, Evers, EG, de Koeijer, A, van Pelt, W, Franz, E, Mevius, DJ, Heederik, DJJ. (2019). Attributable Sources of Community-Acquired Carriage of Escherichia coli Containing β-Lactam Antibiotic Resistance Genes: A Population-Based Modelling Study. The Lancet Planetary Health, 3, pp. 357- 369. DOI: https://doi.org/10.1016/S2542-5196(19)30130-5

OpenAIRE Publications

Project Events

More information coming soon

Project Deliverables

D1.1 – Establishment of a database of synthetic, reference and genomic data

D1.2 – Establishment of a database of field (meta-)genomic data

D1.3- Automated assembly pipeline integrating de novo plasmid reconstruction

D1.4- Test and parameterization of the assembly pipeline for metagenomics data

D1.5- Biological annotations of plasmid identified in the pipeline

D1.6-1.7 GWAS-based method for genomic data analysis / Development of regression model for genomic data analysis

D2.1- Pharmacodynamics and transmission models

D2.2- A risk assessment to predict the sustainability of ESBL-producing E.Coli carriage within commercial pig farms

D2.3- The relevance of transmission routes of antibiotic resistant bacteria calculated using different methodologies and the relevance of routes

D2.4- Report on intervention strategies

D3.1- Inventory of available exposure assessment models and related data and transfer to FSK Standard

D3.2- Scientific report on a generic model for the chicken production chain

D3.3- Scientific Report on an adapted model fort he pork production chain

D3.4- Scientific report on a model of AMR exposure through shellfish consumption

D3.5- Scientific report on a generic comparative exposure assessment model

D3.6- Comparative Exposure Assessment of ESBL-Producing Escherichia coli Through Seafood Consumption

D4.1- Machine learning methods for quantification of risk and health effects

D5.1- Methodology to estimate the disease burden attributable to antimicrobial resistance

D5.2- A proposal for a new paradigm for AMR surveillance

D5.3- Attributable sources of community-acquired carriage of Escherichia coli containing β-lactam antibiotic resistance genes

D6.1- Integration of information by Bayesian evidence synthesis

wso shellkadına özelkadın newsbacklink albacklink satışinstagram takipçi hilesimeme küçültmewso shellworld newstatto girlshacklink seoseo analysismakale programıbacklink salessite analysispubg hile alseo sorgulamahacklink panelseo analysisseo sorgulagoogle newshacklink satışbacklinkbacklink satışseo araclarıseo analizsite analizAntalya Escortwebroot shellbypass shellr57 shelladana escortcanlı bahisadana eskortnevşehir escortbedava bonus veren bahis siteleribedava bonusdeneme bonusu30 tl bonus veren bahis sitelerihoşgeldin bonusuhoşgeldin bonusu veren bahis siteleribahis siteleribahiskaçak iddaacanlı bahisTürkçe Bahis Şirketlerisex hikayeleriporno hikayelerkayseri escortpendik escortsex hikayependik escorttuzla escortpendik escortkurtkoy escortkartal escortapartman kamera sistemikamera sistemimaltepe escortporno izleporno izleümraniye escortizmit escort bayankocaeli escort bayanizmit escortc99 shellc99 shellhtml kod şifrelemeseo newshacklinkbacklink alçorlu escortçerkezköy escortsivas escortmanisa escortizmir escorthatay escorterzurum escortbalikesir escorturfa escorttrabzon escorttekirdag escortsamsun escortadana escortankara escortantep escortaydin escortbursa escortdenizli escortsakarya escortordu escortmugla escortdiyarbakir escorteskisehir escortkayseri escortkocaeli escortkonya escortmalatya escortmaras escortmardin escortmersin escortizmir escortankara escortmersin escorteskişehir escortgaziantep escortsakarya escortkayseri escortantalya escortistanbul escortbursa escortadana escortwso shellsite hız testiadıyamanescortafyon escortağrı escortaksaray escortamasya escortardahan escortartvin escortaydın escortbalıkesir escortbartın escortbatman escortbayburt escortbilecik escortbingöl escortbitlis escortçanakkale escortçankırı escortçorum escortdenizli escortdiyarbakır escortdüzce escortedirne escortelazığ escorterzincan escortbolu escortburdur escortgümüşhane escorthatay escortığdır escortısparta escortmaraş escortkarabük escortkars escortkastamonu escortkilis escortkırıkkale escortkırklareli escortkırşehir escortkocaeli escortkonya escortkütahya escortmalatya escortmanisa escortmardin escortmuğla escortmuş escortnevşehir escortniğde escortordu escortosmaniye escortrize escortsamsun escorturfa escortsiirt escortsinop escortşırnak escortsivas escorttekirdağ escorttokat escorttrabzon escorttunceli escortuşak escortvan escortyozgat escortyalova escortzonguldak escortkıbrıs escortpendik escortesenyurt escortzeytinburnu escortküçükçekmece escortbeşiktaş escorttuzla escortbeykoz escortfatih escortsancaktepe escortarnavutköy escortbağcılar escortümraniye escortbeyoğlu escortüsküdar escortesenler escortmecidiyeköy escortsarıyer escortetiler escortlevent escortbebek escortgaziosmanpaşa escortkartal escortbaşakşehir escortşişli escorthalkalı escortbahçelievler escortortaköy escorteyüp escortbahçeşehir escortkağıthane escorttaksim escortçekmeköy escortsultançiftliği escortşaşkınbakkal escortbayrampaşa escortbeylikdüzü escortkadıköy escortataşehir escortbakırköy escortmerter escortataköy escortnişantaşı escortkozyatağı escortavcılar escortbüyükçekmece escortkurtköy escortiçerenköy escortküçükyalı escortbostancı escortşirinevler escorterenköy escortadana escortadıyaman escortafyon escortağrı escortaksaray escortamasya escortankara escortantalya escortardahan escortartvin escortaydın escortbalıkesir escortbartın escortbatman escortbayburt escortbilecik escortbingöl escortbitlis escortbolu escortburdur escortbursa escortçanakkale escortçankırı escortçorum escortdenizli escortdiyarbakir escortdüzce escortedirne escortelazığ escorterzincan escorterzurum escorteskişehir escortantep escortgiresun escortgümüşhane escorthakkari escorthatay escortığdır escortistanbul escortizmir escortkarabük escortkaraman escortkars escortkastamonu escortkayseri escortkıbrıs escortkilis escortkırıkkale escortkırklareli escortkırşehir escortkocaeli escortkonya escortkütahya escortmalatya escortmanisa escortmaraş escortmardin escortmersin escortmuğla escortmuş escortnevşehir escortniğde escortordu escortosmaniye escortrize escortsakarya escortsamsun escortsiirt escortsinop escortmozrankGameloopporno izleçekiliş sitesihtml code encryptionserver scanwso shelloyun indirsunucu taramasite speed testinstagram takipçi hilesiWordpress Free Themeswordpress free temahtml kod şifrelemesunucu taramaTanıtım Yazısıwordpress themesseowordpress ücretsiz temaWho islogsuz shell indirlitespeed bypass shellindoxploit shellphp shellgoogle sıra buluculitespeed bypass shellbacklink sorgulamaeryaman escortistanbul bayan escortankara escorthacklink satışbacklink satışhacklink panelhacklinkerzurum escortgiresun escortbest stethoscoperaycon reviewsBest Dog Crateshapermint bra reviewswireless earbudsBest Gaming Monitorsviagra siparişlifta 20 mgcialis fiyatviagra 100 mg fiyatcialis jelviagra satın alcialis 5 mg fiyatviagra satın alviagra fiyatıdegravigrandedegra 100 mgorcafilcialis nedircialis 20 mg eczane fiyatıcialis fiyatcialis 20 mgcialis 100 mgviagra fiyatliftalifta 5 mghardciscialis eczanecialis 5 mg fiyatıcialis 100 mg fiyatcialis 5 mgviagra fiyatlarıviagra satışonline eczane viagraviagra eczanecialis 20 mgcialis 100 mgcialis hapcialis 20cialis eczanecialis satışcialis fiyatlarıcialis fiyatıviagra fiyatviagra fiyatlarıviagra eczaneviagra satın alpfizer viagra satışonline eczane viagrapfizer viagra satın alviagra siparişviagra sipariş hattıviagra fiyat 2021online viagra siparişviagra fiyat 2021 eczaneviagra fiyat eczanecialis 5 mgkamagra satın alkamagrakamagra jelkamagra jel siparişkamagra siparişkamagra fiyatkamagra jel fiyatıkamagra fiyatıkamagra 100mgkamagra 100mg fiyatsüper kamagrakamagra nedirSincan escortAnkara rus escortsultangazi escortbingöl escortsancaktepe escorteskişehir escortkırklareli escortçekmeköy escortbodrum escortkuşadası escortc99 shellc99 shelllifta 20 mgliftalifta 20lifta 20 mg nedirlifta nedirhacklink seokuşadası escortbeylikdüzü escortkarşıyaka escortgöztepe escortbornova escortçeşme escortbuca escortalsancak escortkonak escort