TRACE

TRACE: Tracking the public health hazard of foodborne Hepatitis E

               Start: September 2019

               Duration: 4 years

               Research Domain: Foodborne Zoonoses

               Members: RIVM, WbvR- the Netherlands, ANSES- France

               Contact: Dr. Eelco Franz

The Project

Hepatitis E virus (HEV) is a zoonotic virus responsible of acute hepatitis E in human in Western countries. HEV is widespread in a number of animal species but the major animal reservoirs of HEV are domestic and wild pigs shedding HEV into the environment. However, the main route of HEV transmission in Europe is through consumption of contaminated pork. Consumption of raw or undercooked pork products have been associated to clinical Hepatitis E.  Molecular analyses showed that HEV strains detected in pigs and humans in the same geographical region present high genetic identity, indicating that swine are the main source of infection for humans. In European countries more than 50% of the pig farms may be affected and seroprevalence within these farms can be over 80%. To identify the contamination sources of HEV in humans, HEV sequencing, genotyping and subgenotyping is often used. Regarding HEV subgenotypes in recent years in North-West Europe, a shift is seen towards HEV subgenotype 3c. It is unknown if this is a shift towards a more virulent or a more contagious HEV variant. Since 2014, an increase in clinical cases has been observed in many EU member states including the Netherlands. During the summer of 2017 and 2018 in the Netherlands, a temporal drop was observed in acute HEV clinical infections, after which the incidence went back up to similar numbers as had been observed before. These events have remained unexplained to this date. To explain the predominance of certain HEV variants and to elucidate differences in virulence, we will characterize HEV variants and attempt to identify virulence factors in HEV strains detected in clinical HEV patients, in the general population and in domestic swine. Given the high genetic diversity of HEV it is critical to obtain higher resolution genomic data (i.e. whole genome sequences) in order to gain more understanding on its molecular epidemiology and possible variations in patho-adaptive traits.

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